The draw for the fifth round of the FA Cup was conducted on Monday night.
Manchester City, who eliminated Arsenal in the previous round, are away at Bristol City.
Their city rivals Manchester United will host either Derby County or West Ham in the round of 16.
Tottenham Hotspur will travel to face either Wrexham or Sheffield United.
The draw in full:
Southampton vs Luton/Grimsby
Leicester City vs Blackburn/Birmingham City
Stoke vs Brighton
Wrexham/Sheffield United vs Tottenham
Fulham/Sunderland vs Leeds
Bristol City vs Man City
Man Utd vs Derby/West Ham
Ipswich/Burnley vs Sheffield Wednesday/Fleetwood